The intestinal tissue is continuously exposed to large amounts of microbe– and food–derived molecules that can stimulate immune responses. We study how the intestine generates protective responses against invading pathogens (resistance) while absorbing beneficial microbe– and food–derived molecules (tolerance). Several cellular and molecular mechanisms exist to ensure robust tolerance induction in the mucosal surfaces, and disruption of such processes often leads to severe chronic inflammatory pathologies such as colitis, Celiac disease and food allergies, and colorectal cancer. We seek to understand how immunity against microbiota and food are generated and how they can contribute to the maintenance of intestinal homeostasis while protecting us from invading pathogens.
We are seeking two motivated and detail-oriented individuals to join our research team as Research Assistants. As a key member of our team, you will play a crucial role in supporting our research and contributing to the understanding of the development and function of the intestinal immune system. Specific projects focus on dissecting the immune responses against gut microbiota, food and cancer, as well as understanding both genetic and environmental drivers of intestinal immune phenotypes. The Research Assistants will use mouse models to assess gut immune cells by flow cytometry and RNA-sequencing and will be responsible for animal colony maintenance. Other technical responsibilities may include bacterial and mammalian cell culture (including organoid cultures), ELISA, and immunoblotting, as well as molecular biology techniques such as cloning, RNA/DNA extractions, PCR and single-cell PCRs.
The Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above.
The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.